Pearce V R, Antcliff A C, Beevers D G, Hamilton M
Postgrad Med J. 1978 Aug;54(634):533-7. doi: 10.1136/pgmj.54.634.533.
The use of amiloride is described in twenty-four hypertensive patients who became hypokalaemic as a result of thiazide diuretic therapy in spite of oral potassium supplments. Amiloride caused a significant rise in exchangeable potassium, exchangeable potassium/kg body weight, and plasma potassium, together with a significant fall in plasma total carbon dioxide, body weight, systolic and diastolic blood pressures. These results suggest that amiloride has a useful role in this type of patient.
24名高血压患者在接受噻嗪类利尿剂治疗且口服补钾的情况下仍出现低钾血症,对这些患者使用了氨氯吡咪。氨氯吡咪使可交换钾、每千克体重可交换钾及血浆钾显著升高,同时使血浆总二氧化碳、体重、收缩压和舒张压显著降低。这些结果表明氨氯吡咪在这类患者中具有有益作用。