色甘酸钠对过度通气诱发的哮喘发作的影响。
Effect of disodium cromoglycate on exacerbations of asthma produced by hyperventilation.
作者信息
Clarke P S
出版信息
Br Med J. 1971 Feb 6;1(5744):317-9. doi: 10.1136/bmj.1.5744.317.
Abstract
The prophylactic inhalation of disodium cromoglycate lessens the exacerbations which occur in some asthmatic patients after voluntary hyperventilation. Reasons are given for considering this to be a possible mechanism for certain types of emotional exacerbation of the disease and for disodium cromoglycate giving sypmtomatic relief of asthma disproportionate to the improvement in routine measurements of ventilatory capacity. It is suggested that one clinical indication for giving disodium cromoglycate is to observe whether a fall in FEV(1) occurs after two minutes hyperventilation.
摘要
预防性吸入色甘酸钠可减轻一些哮喘患者在自主过度通气后出现的病情加重。文中给出了理由，认为这可能是该疾病某些类型情绪性加重的一种机制，也是色甘酸钠能缓解哮喘症状但与通气能力常规测量指标改善不成比例的原因。有人提出，给予色甘酸钠的一个临床指征是观察在过度通气两分钟后第一秒用力呼气量（FEV₁）是否下降。
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