运动性哮喘与色甘酸钠
Exercise asthma and disodium cromoglycate.
作者信息
Poppius H, Muittari A, Kreus K E, Korhonen O, Viljanen A
出版信息
Br Med J. 1970 Nov 7;4(5731):337-9. doi: 10.1136/bmj.4.5731.337.
Abstract
Exercise-induced asthma (defined as a fall in PEF of at least 25% of the pre-exercise value) was studied in adult patients with uncomplicated asthma. This was found to occur in 22 out of 52 patients. Pre-exercise inhalation of disodium cromoglycate reduced the mean fall in PEF after maximal exercise from 50% of the pre-exercise value to 23% (open assessment in 11 cases). After submaximal exercise for eight minutes the reduction was from 18% to 10% (double-blind crossover study in 28 cases). It is concluded that disodium cromoglycate partly inhibits the increase of airways resistance after exercise in asthmatic patients.
摘要
在无并发症的成年哮喘患者中研究了运动诱发性哮喘（定义为运动后呼气峰流速（PEF）下降至少达到运动前值的25%）。发现52例患者中有22例出现这种情况。运动前吸入色甘酸钠可使最大运动后PEF的平均下降幅度从运动前值的50%降至23%（11例开放评估）。在进行8分钟次最大运动后，下降幅度从18%降至10%（28例双盲交叉研究）。结论是色甘酸钠可部分抑制哮喘患者运动后气道阻力的增加。
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