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相似文献

1
Analysis of immunological memory in terms of increased PFC responsiveness and increased focus-forming capacity.从增强的PFC反应性和增强的集落形成能力方面分析免疫记忆。
Immunology. 1971 Feb;20(2):241-5.
2
Studies on the cellular basis of IgM immunological memory.IgM免疫记忆细胞基础的研究。
Immunology. 1969 May;16(5):621-32.
3
The effect of x-irradiation of the appearance of antibody-forming cells in the mouse spleen following the injection of sheep erythrocytes.注射绵羊红细胞后，X射线照射对小鼠脾脏中抗体形成细胞出现的影响。
Eur J Immunol. 1973 Nov;3(11):698-703. doi: 10.1002/eji.1830031109.
4
Studies on the cellular basis of IgM immunological memory. The induction of antibody formation in bone marrow cells by primed spleen cells.关于IgM免疫记忆细胞基础的研究。经致敏的脾细胞诱导骨髓细胞产生抗体。
Immunology. 1969 Dec;17(6):933-42.
5
Immune responses in aged mice: changes of antibody-forming cell precursors and antigen-reactive cells with ageing.老年小鼠的免疫反应：抗体形成细胞前体和抗原反应性细胞随衰老的变化。
Clin Exp Immunol. 1971 Jun;8(6):957-62.
6
The effect of single large dose hydrocortisone treatment on IgM and IgG antibody production, morphological distribution of antibody producing cells and immunological memory.单次大剂量氢化可的松治疗对IgM和IgG抗体产生、抗体产生细胞的形态分布及免疫记忆的影响。
Immunology. 1971 Jul;21(1):151-8.
7
Antibody-mediated suppression of the immune response: effect on the development of immunologic memory.抗体介导的免疫反应抑制：对免疫记忆形成的影响。
J Immunol. 1971 Nov;107(5):1213-25.
8
The functions of immune T and B rosette-forming cells.免疫T和B玫瑰花结形成细胞的功能。
Immunology. 1973 Aug;25(2):158-96.
9
[Immunological reactivation of irradiated mice by means of syngeneic cell transfer].[通过同基因细胞转移对受辐照小鼠进行免疫激活]
Allerg Immunol (Leipz). 1973;19(2-4):178-84.
10
[Immunological defense capacity in persons of advanced age].[老年人的免疫防御能力]
Zentralbl Bakteriol Orig A. 1974;227(1-4):212-7.

本文引用的文献

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Cellular basis of the immunological defects in thymectomized mice.胸腺切除小鼠免疫缺陷的细胞基础。
Nature. 1967 Jun 3;214(5092):992-7. doi: 10.1038/214992a0.
2
The mitotic response of thymus-derived cells to antigenic stimulus.胸腺来源细胞对抗抗原刺激的有丝分裂反应。
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A transplantation assay for mouse cells responsive to antigenic stimulation by sheep erythrocytes.一种针对对绵羊红细胞抗原刺激有反应的小鼠细胞的移植试验。
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Cellular differentiation of the immune system of mice. II. Frequency of unipotent splenic antigen-sensitive units after immunization with sheep erythrocytes.小鼠免疫系统的细胞分化。II. 用绵羊红细胞免疫后单能脾抗原敏感单位的频率。
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5
Further characterization of the lymphoid cell transfer system for the study of antigen-sensitive progenitor cells.用于研究抗原敏感祖细胞的淋巴细胞转移系统的进一步特性分析。
J Immunol. 1968 Nov;101(5):963-72.
6
Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes.免疫反应中的细胞间相互作用。II. 给受照射小鼠输注骨髓、胸腺或胸导管淋巴细胞后溶血素形成细胞的来源。
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7
Kinetic study of the production of antibody-forming cells from their precursors.抗体形成细胞从前体细胞产生的动力学研究。
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8
Recovery of immune responsiveness in lethally-irradiated mice protected with syngeneic marrow cells.用同基因骨髓细胞保护的致死性照射小鼠免疫反应性的恢复。
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9
Immunological activity of thymus and thoracic-duct lymphocytes.胸腺和胸导管淋巴细胞的免疫活性
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10
Cellular differentiation of the immune system of mice. IV. Lack of class differentiation in thymic antigen-reactive cells.小鼠免疫系统的细胞分化。IV. 胸腺抗原反应性细胞中缺乏类别分化。
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从增强的PFC反应性和增强的集落形成能力方面分析免疫记忆。

Analysis of immunological memory in terms of increased PFC responsiveness and increased focus-forming capacity.

作者信息

Gregory C J

出版信息

Immunology. 1971 Feb;20(2):241-5.

PMID:5102246
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1455814/
Abstract

The increase in splenic plaque-forming cell (PFC) responsiveness which occurs in mice following the injection of a primary dose of 10 sheep red blood cells was measured using the spleen cell transfer system. As for grafts of normal spleen cells, the peak direct (19S) and indirect (7S) responses obtained with grafts of primed spleen cells were found to be related to the number of cells transferred in a near-parabolic fashion. Splenic direct PFC responsiveness as measured by the regression defining the corresponding graft-response relationship was increased about five times 4 weeks after priming; focus-forming capacity was also increased by a similar factor. At the same time indirect PFC responsiveness was increased almost twenty times. These results are discussed in terms of antigen-induced changes in the populations of PFC precursors and antigen-reactive auxiliary cells in the spleen.

摘要

利用脾细胞转移系统，测定了注射10个初剂量绵羊红细胞后小鼠脾中形成斑块细胞（PFC）反应性的增加情况。对于正常脾细胞移植，发现用经致敏脾细胞移植获得的峰值直接（19S）和间接（7S）反应与以近似抛物线方式转移的细胞数量有关。通过定义相应移植反应关系的回归测量，致敏后4周脾直接PFC反应性增加了约5倍；聚焦形成能力也增加了类似的倍数。同时，间接PFC反应性增加了近20倍。根据抗原诱导的脾中PFC前体细胞群和抗原反应性辅助细胞群的变化对这些结果进行了讨论。