吗啡在人体内的处置。
Disposition of morphine in man.
作者信息
Spector S, Vesell E S
出版信息
Science. 1971 Oct 22;174(4007):421-2. doi: 10.1126/science.174.4007.421.
PMID:5111997
Abstract
The disposition of morphine was investigated by means of radioimmunoassay after a single intravenous dose (10 milligrams per 70 kilograms) was administered to 10 adult normal male subjects who had not received other drugs for 2 weeks preceding the study. A multiphasic decline in serum concentrations of morphine occurred. Detectable blood concentrations of morphine, or of a metabolite, or of both persisted for 48 hours after a single intravenous dose.
摘要
在对10名成年正常男性受试者单次静脉注射剂量（每70千克体重10毫克）吗啡后，通过放射免疫测定法研究了吗啡的处置情况。这些受试者在研究前2周未服用其他药物。吗啡血清浓度呈多相下降。单次静脉注射剂量后，吗啡、其代谢产物或两者的可检测血药浓度持续48小时。
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