一种实现静脉注射药物快速稳态血药浓度的方法。

A method for achieving rapidly steady-state blood concentrations of I.V. drugs.

作者信息

Rigg J R, Wong T Y

出版信息

Br J Anaesth. 1981 Dec;53(12):1247-57. doi: 10.1093/bja/53.12.1247.

DOI:10.1093/bja/53.12.1247

Abstract

The theoretical basis of a pharmacokinetic method to obtain rapidly and maintain a steady plasma concentration of an i. v. drug is described. Computer simulations of morphine disposition in man, using pharmacokinetic constants obtained from the literature, are provided as examples of steady-state dose regimens. The usefulness and potential limitations of the method are discussed.

摘要

本文描述了一种通过静脉注射药物快速达到并维持稳定血药浓度的药代动力学方法的理论基础。利用从文献中获取的药代动力学常数，对吗啡在人体中的处置进行了计算机模拟，作为稳态给药方案的示例。讨论了该方法的实用性和潜在局限性。