通过生物膜的被动不对称运输。
Passive asymmetric transport through biological membranes.
作者信息
Schultz J S
出版信息
Biophys J. 1971 Nov;11(11):924-43. doi: 10.1016/S0006-3495(71)86264-1.
Abstract
The magnitude of passive diffusional solute transfer through artificial membranes is usually considered to be independent of the direction of the concentration gradient driving force. It can be shown, however, that a composite membrane, having as one component a membrane with a chemical reaction-facilitated diffusion transport mechanism, can result in an asymmetrical flux. An asymmetric flux caused by this type of structural heterogeneity may be one mechanism contributing to the asymmetric properties of biological membranes. Similar vectorial fluxes can be generated in interfacial solute transfer through membranes if hydrodynamic boundary layers occur at the membrane interface and reversible chemical reactions with the permeant species are involved in either phase.
摘要
通常认为，溶质通过人工膜的被动扩散转移量与驱动浓度梯度的方向无关。然而，可以证明，一种复合膜，其一种成分是具有化学反应促进扩散传输机制的膜，可能会导致通量不对称。这种结构异质性引起的不对称通量可能是导致生物膜不对称特性的一种机制。如果在膜界面处出现流体动力边界层，并且在任一相中都涉及与渗透物质的可逆化学反应，那么在通过膜的界面溶质转移中也可以产生类似的矢量通量。
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