Boya J, Calvo J, Prado A
J Anat. 1979 Aug;129(Pt 1):177-86.
The rat brain has been studied between 6 hours after birth and 100 days, using histochemical techniques for acid phosphatase and peroxidase, and silver impregnation for microglial cells. The results indicate that microglia come initially from acid phosphatase-positive cells of the meninges. These invade the nervous parenchyma and transform into ramified microglia. At 3 days of age similar cells are present on the outer surface of the large blood vessels, from which site they migrate into the nervous parenchyma. In 100 days old rats the acid phosphatase-positive cells are practically all pericytes. None of the microglial cells or their precursors give a positive reaction for peroxidase.
利用酸性磷酸酶和过氧化物酶的组织化学技术以及对小胶质细胞的银浸染法，对出生后6小时至100天的大鼠脑进行了研究。结果表明，小胶质细胞最初来源于脑膜中酸性磷酸酶阳性细胞。这些细胞侵入神经实质并转化为分支状小胶质细胞。在3日龄时，类似的细胞存在于大血管的外表面，它们从该部位迁移到神经实质。在100日龄的大鼠中，酸性磷酸酶阳性细胞几乎都是周细胞。小胶质细胞及其前体细胞均未对过氧化物酶产生阳性反应。
