Lunzer M R, Newman S P, Bernard A G, Manghani K K, Sherlock S P, Ginsburg J
Lancet. 1975 Aug 30;2(7931):382-5. doi: 10.1016/s0140-6736(75)92896-2.
Cardiovascular responsiveness to reflex impaired in patients with cirrhosis compared with control subjects. Peripheral vascular responses to exogenous noradrenaline were also impaired in cirrhotic patients, but peripheral vascular responses to infused adrenaline and to angiotensin II were similar in both groups. Impaired cardiovascular reactivity in patients with chronic liver disease could predispose them to circulatory failure after haemorrhage or surgery and should be considered when prescribing drugs which affect autonomic activity.
与对照组相比，肝硬化患者心血管对反射的反应性受损。肝硬化患者对外源性去甲肾上腺素的外周血管反应也受损，但两组对外源性肾上腺素和血管紧张素II的外周血管反应相似。慢性肝病患者心血管反应性受损可能使他们在出血或手术后易发生循环衰竭，在开具影响自主神经活动的药物时应予以考虑。
