Adler A, Safai B
J Am Acad Dermatol. 1979 Oct;1(4):305-9. doi: 10.1016/s0190-9622(79)70023-5.
The involvement of the humoral and cell-mediated immune systems in the regression of wart infection has been investigated extensively in recent years. This review examines the supporting evidence for the roles of humoral and cellular immunity in wart regression and its possible implications. From the available data it does not appear that a conclusion can be drawn that only humoral or cell-mediated immunity is involved, or that both are essential, in the regression of wart infection. Studies by several investigators, however, suggest that, since agents known to stimulate the cell-mediated immune system have been reported to be followed by the successful resolution of warts, the cell-mediated immune system appears to play a critical role in wart resolution. It may be that the direction which should be taken in eradication of warts resistant to conventional modalities of treatment is one which relies upon the stimulation of the patient's immune system in a very specific manner. Probably the most efficient way to accomplish this, based on available data, would be by autogenous vaccination. Following the patient's humoral and cell-mediated immune response prior to, during, and following treatment with autogenous vaccination may help to elucidate the precise mechanism by which the successful resolution of warts occurs.
近年来，体液免疫和细胞介导的免疫系统在疣感染消退过程中的作用已得到广泛研究。本综述探讨了体液免疫和细胞免疫在疣消退中作用的支持证据及其可能的影响。从现有数据来看，似乎无法得出仅涉及体液免疫或细胞介导免疫，或者两者在疣感染消退中都必不可少的结论。然而，几位研究者的研究表明，由于据报道已知刺激细胞介导免疫系统的药物之后疣会成功消退，所以细胞介导的免疫系统似乎在疣的消退中起关键作用。也许在根除对传统治疗方式有抗性的疣时应采取的方向是非常具体地依赖于刺激患者的免疫系统。基于现有数据，实现这一点最有效的方法可能是自体接种疫苗。在自体接种疫苗治疗之前、期间和之后跟踪患者的体液免疫和细胞介导免疫反应，可能有助于阐明疣成功消退的精确机制。
