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人乳头瘤病毒抗原对人淋巴细胞的体外刺激作用。

In vitro lymphocyte stimulation by wart antigen in man.

作者信息

Ivanyi L, Morison W L

出版信息

Br J Dermatol. 1976 May;94(5):523-7. doi: 10.1111/j.1365-2133.1976.tb05140.x.

DOI:10.1111/j.1365-2133.1976.tb05140.x
PMID:1268063
Abstract

The lymphocyte transformation test was used to study cell-mediated immunity to wart antigen in patients with active wart infections, in patients with past history of warts and in control subjects. A common pattern was established with wart antigen; a control baseline, followed by a rise of 14C thymidine uptake in the 'active' group and a further elevation in the 'past history' group. Five patients with active warts were followed up and re-examined at various intervals after successful wart resolution; all except one responded to wart antigen by increased DNA synthetic activity after the wart resolution. This increased response was specific for wart antigen and could still be detected 6 months after wart resolution.

摘要

采用淋巴细胞转化试验研究了患有活动性疣感染的患者、有疣病史的患者以及对照受试者对疣抗原的细胞介导免疫。用疣抗原建立了一种常见模式:一个对照基线,随后“活动性”组中14C胸苷摄取量增加,“有病史”组进一步升高。对5例患有活动性疣的患者在疣成功消退后的不同时间间隔进行了随访和复查;除1例患者外,所有患者在疣消退后对疣抗原的反应均表现为DNA合成活性增加。这种增强的反应对疣抗原具有特异性,并且在疣消退后6个月仍可检测到。

相似文献

1
In vitro lymphocyte stimulation by wart antigen in man.人乳头瘤病毒抗原对人淋巴细胞的体外刺激作用。
Br J Dermatol. 1976 May;94(5):523-7. doi: 10.1111/j.1365-2133.1976.tb05140.x.
2
Cell-mediated immunity (CMI) to human wart virus and wart-associated tissue antigens.针对人乳头瘤病毒和疣相关组织抗原的细胞介导免疫(CMI)。
Clin Exp Immunol. 1976 Dec;26(3):419-24.
3
In vitro assay of immunity to human wart antigen.
Br J Dermatol. 1975 Nov;93(5):545-52. doi: 10.1111/j.1365-2133.1975.tb02247.x.
4
Immunity in wart resolution.疣消退过程中的免疫
J Am Acad Dermatol. 1979 Oct;1(4):305-9. doi: 10.1016/s0190-9622(79)70023-5.
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Generalized warts and immune deficiency.
Br J Dermatol. 1976 Nov;95(5):559-64. doi: 10.1111/j.1365-2133.1976.tb00870.x.
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Intralesional injection of mumps or Candida skin test antigens: a novel immunotherapy for warts.病灶内注射腮腺炎或念珠菌皮肤试验抗原:一种治疗疣的新型免疫疗法。
Arch Dermatol. 2001 Apr;137(4):451-5.
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[Immunology of human warts (author's transl)].[人类疣的免疫学(作者译)]
Ann Dermatol Venereol. 1978 Mar;105(3):257-64.
8
Immunological aspects of wart regression with special reference to regression phenomenon of numerous flat warts. An experiment on tumor immunity in man by nature.
J Dermatol. 1983 Feb;10(1):1-12. doi: 10.1111/j.1346-8138.1983.tb01098.x.
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Acta Derm Venereol. 1978;58(5):427-32.
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An immunoelectron microscopic localization of wart associated antigens present in human papilloma virus (HPV) infected cells.
J Invest Dermatol. 1978 May;70(5):263-6. doi: 10.1111/1523-1747.ep12541415.

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Production and characterization of human proliferative T-cell clones specific for human papillomavirus type 1 E4 protein.针对人乳头瘤病毒1型E4蛋白的人增殖性T细胞克隆的产生与特性分析
J Virol. 1993 May;67(5):2799-806. doi: 10.1128/JVI.67.5.2799-2806.1993.
2
Immunopathology of papillomavirus-induced tumors in different tissues.乳头瘤病毒在不同组织中诱导肿瘤的免疫病理学
Springer Semin Immunopathol. 1982;5(1):33-53. doi: 10.1007/BF00201955.
3
Animal papillomaviruses.动物乳头瘤病毒。
Microbiol Rev. 1982 Jun;46(2):191-207. doi: 10.1128/mr.46.2.191-207.1982.
4
The relation between the type of immunoreactive cells found in human papillomavirus (HPV) lesions of the uterine cervix and the subsequent behaviour of these lesions.在子宫颈人乳头瘤病毒(HPV)病变中发现的免疫反应性细胞类型与这些病变后续行为之间的关系。
Arch Gynecol. 1984;234(3):189-96. doi: 10.1007/BF00570755.
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Lymphoproliferative response to fusion proteins of human papillomaviruses in patients with cervical intraepithelial neoplasia.宫颈上皮内瘤变患者对人乳头瘤病毒融合蛋白的淋巴细胞增殖反应。
Epidemiol Infect. 1989 Dec;103(3):625-32. doi: 10.1017/s0950268800031022.
6
Specific immunity to human papilloma virus (HPV) in patients with genital warts.
Br J Vener Dis. 1978 Jun;54(3):172-5. doi: 10.1136/sti.54.3.172.
7
Comparative study of delayed hypersensitivity skin reactions and antibodies to human papilloma virus (HPV).人乳头瘤病毒(HPV)迟发型超敏皮肤反应与抗体的对比研究
Clin Exp Immunol. 1977 Aug;29(2):240-6.