Borer K T, Potter C D, Fileccia N
Physiol Behav. 1983 Mar;30(3):389-97. doi: 10.1016/0031-9384(83)90142-7.
The pattern of hypoactivity that accompanies rapid weight gain following septal lesions in hamsters was characterized. Lesioned hamsters displayed reduced levels of running, shorter and slower running bouts, and longer pauses. We examined whether this hypoactivity was due to reassignment of metabolic fuels from supporting physical activity to anabolism, or due to reduced capacity of running to induce psychomotor arousal and mobilize metabolic fuels. Septal lesions were associated with increased rate of ponderal growth and higher titers of circulating growth hormone and insulin. No difference in concentrations of muscle and liver glycogen, percentage of body fat, or the capacity of muscle homogenates to oxidize substrates were identified. Lesioned hamsters ran as fast and as long as control animals on electrical-shock reinforced treadmill, but were unable to generate as much heat in response to injection (0.8 mg/kg) of norepinephrine. We concluded that hypoactivity that accompanies rapid weight gain in hamsters results either from a reduced capacity of running to induce psychomotor arousal and provide incentives that normally motivate that behavior, or from a failure of running to mobilize metabolic fuels at a rate necessary to sustain normal running speed and duration, and not from reduced availability of metabolic fuels or reduced muscle capacity to oxidize metabolic substrates.
对仓鼠隔区损伤后伴随体重快速增加的活动减退模式进行了表征。损伤的仓鼠表现出跑步水平降低、跑步时间缩短且速度减慢以及停顿时间延长。我们研究了这种活动减退是由于代谢燃料从支持身体活动重新分配到合成代谢，还是由于跑步诱导精神运动觉醒和调动代谢燃料的能力降低。隔区损伤与体重增加速率加快以及循环生长激素和胰岛素水平升高有关。未发现肌肉和肝糖原浓度、体脂百分比或肌肉匀浆氧化底物的能力存在差异。损伤的仓鼠在电击强化跑步机上的奔跑速度和时间与对照动物相同，但对注射（0.8毫克/千克）去甲肾上腺素的反应无法产生同样多的热量。我们得出结论，仓鼠体重快速增加时伴随的活动减退要么是由于跑步诱导精神运动觉醒并提供通常激发该行为的动机的能力降低，要么是由于跑步调动代谢燃料的速率无法维持正常跑步速度和持续时间，而不是由于代谢燃料可用性降低或肌肉氧化代谢底物的能力降低。
