Filler R, Criss W E
Biochem J. 1971 May;122(4):553-5. doi: 10.1042/bj1220553.
Total adenylate kinase activity was determined in developing rat liver. The activity was 18 units/g wet weight of tissue in foetal liver; this increased to 41 units/g immediately after birth and continued increasing until adult activities of 150 units/g were reached after two weeks. The adenylate kinase activity was separated into four isoenzymes. Only isoenzymes II and III were observed in foetal rat liver. Isoenzyme II activity was 2 units/g in the foetal liver and increased to 25 units/g in adult liver. Adenylate kinase III activity was 20 units/g in the foetal liver and increased to 118 units/g in adult liver. The possible role that adenylate kinase might have in regulating the energy flow in the developing liver cell is discussed.
测定了发育中的大鼠肝脏中腺苷酸激酶的总活性。在胎儿肝脏中,该活性为每克湿组织18单位;出生后立即增至每克41单位,并持续增加,直至两周后达到成体水平的每克150单位。腺苷酸激酶活性被分离为四种同工酶。在胎鼠肝脏中仅观察到同工酶II和III。同工酶II活性在胎儿肝脏中为每克2单位,在成体肝脏中增至每克25单位。腺苷酸激酶III活性在胎儿肝脏中为每克20单位,在成体肝脏中增至每克118单位。本文讨论了腺苷酸激酶在调节发育中肝细胞能量流方面可能发挥的作用。