Tam Y K, Axelson J E, Ongley R
J Pharm Sci. 1979 Oct;68(10):1254-6. doi: 10.1002/jps.2600681015.
A modified electron-capture GLC assay for metoclopramide in human biological specimens is reported. This assay involves the incorporation of a back-extraction method to remove endogenous contaminants. Its applicability was demonstrated by studying the time course of metoclopramide in plasma and urine from a human subject. The lowest quantifiable metoclopramide concentration in plasma was 7 ng/ml, provided 0.5 ml of plasma was used.
本文报道了一种用于测定人体生物样本中胃复安的改良电子捕获气相色谱法。该方法采用反萃取法去除内源性污染物。通过研究一名人体受试者血浆和尿液中胃复安的时间进程，证明了该方法的适用性。若使用0.5 ml血浆，血浆中胃复安的最低可定量浓度为7 ng/ml。
