Wood R W, Welles H L
J Pharm Sci. 1979 Oct;68(10):1272-4. doi: 10.1002/jps.2600681020.
A procedure was developed for measuring small amounts of phenylmercuric nitrate in aqueous solutions. The method depends on the formation of insoluble phenylmercuric iodide upon titration of phenylmercuric nitrate with potassium iodide. The end-point can be detected using an iodide-sensitive electrode. The method is able to measure down to 0.000125% aqueous solution of phenylmercuric nitrate with a 1% accuracy. Procedural details and dexcriptions of excipient effects on the assay are presented. Naphazoline hydrochloride, phenylephrine hydrochloride, fluroescein sodium, and antipyrine interfered with the method, while the common buffer systems, polyvinyl alcohol, sodium thiosulfate, edetate sodium, and chloramphenicol had no effect.
已开发出一种用于测定水溶液中少量硝酸苯汞的方法。该方法基于用碘化钾滴定硝酸苯汞时形成不溶性碘化苯汞。终点可用碘离子敏感电极检测。该方法能够测定低至0.000125%的硝酸苯汞水溶液，准确度为1%。文中给出了操作细节以及辅料对该测定的影响说明。盐酸萘甲唑啉、盐酸去氧肾上腺素、荧光素钠和安替比林会干扰该方法，而常见的缓冲体系、聚乙烯醇、硫代硫酸钠、乙二胺四乙酸钠和氯霉素则无影响。
