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不同实验动物中针对不同抗原的巨噬细胞嗜细胞抗体的检测与产生

The detection and production of macrophage cytophilic antibody to different antigens in different laboratory animals.

作者信息

Liew F Y

出版信息

Immunology. 1971 Dec;21(6):1045-58.

PMID:5129995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1408279/
Abstract

An assay for macrophage cytophilic antibody is described, based on the measurement of the adherence of I-labelled antigen to peritoneal exudate cells pretreated with antiserum. Using this assay, the production of cytophilic antibody to SRBC, BSA, polymerized flagellin, flagellin and a CNBr digest of flagellin was investigated in guinea-pigs, rats, rabbits and mice. Antigens injected in either Freund's complete or incomplete adjuvant were almost equally efficient at inducing cytophilic antibody production. In contrast, antigens injected in saline failed to induce detectable cytophilic antibody. The ratio of cytophilic antibody titre/passive haemagglutinating antibody titre was calculated and it was found that the ratio for rabbit>guinea-pig>mouse>rat. Furthermore, in those sera which were examined, cytophilic antibody was only detected in the 7S fractions.

摘要

本文描述了一种巨噬细胞嗜细胞抗体检测方法，该方法基于测量用抗血清预处理的腹膜渗出细胞对I标记抗原的黏附情况。利用此检测方法，研究了豚鼠、大鼠、家兔和小鼠针对绵羊红细胞（SRBC）、牛血清白蛋白（BSA）、聚合鞭毛蛋白、鞭毛蛋白以及鞭毛蛋白的溴化氰消化产物产生嗜细胞抗体的情况。注射于弗氏完全或不完全佐剂中的抗原在诱导嗜细胞抗体产生方面效率几乎相同。相比之下，注射于盐水中的抗原未能诱导出可检测到的嗜细胞抗体。计算了嗜细胞抗体滴度与被动血凝抗体滴度的比值，发现该比值为兔>豚鼠>小鼠>大鼠。此外，在所检测的血清中，仅在7S组分中检测到嗜细胞抗体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d97/1408279/ca377d19d03c/immunology00359-0170-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d97/1408279/ca377d19d03c/immunology00359-0170-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d97/1408279/ca377d19d03c/immunology00359-0170-a.jpg

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Properties of antibodies cytophilic for macrophages.对巨噬细胞具有亲嗜性的抗体的特性。
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J Exp Med. 1974 Mar 1;139(3):779-84. doi: 10.1084/jem.139.3.779.

本文引用的文献

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CYTOPHILIC ANTIBODY IN GUINEA-PIGS WITH DELAYED-TYPE HYPERSENSITIVITY.迟发型超敏反应豚鼠中的亲细胞抗体
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ANTIGENS IN IMMUNITY. III. DISTRIBUTION OF IODINATED ANTIGENS FOLLOWING INJECTION INTO RATS VIA THE HIND FOOTPADS.免疫中的抗原。III. 经后足垫注射入大鼠体内的碘化抗原的分布
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ANTIGENS IN IMMUNITY. I. PREPARATION AND PROPERTIES OF FLAGELLAR ANTIGENS FROM SALMONELLA ADELAIDE.免疫中的抗原。一、阿德莱德沙门氏菌鞭毛抗原的制备及特性
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The agglutination and sensitization of red cells by metallic cations: interactions between multivalent metals and the red-cell membrane.金属阳离子对红细胞的凝集和致敏作用：多价金属与红细胞膜之间的相互作用。
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The tolerance inducing properties in rats of bacterial flagellin cleaved at the methionine residues.在大鼠中，细菌鞭毛蛋白在甲硫氨酸残基处裂解后的耐受诱导特性。
Immunology. 1969 Aug;17(2):153-64.
8
Specific inactivation of antigen-reactive cells with 125I-labelled antigen.用125I标记的抗原特异性灭活抗原反应性细胞。
Nature. 1969 Jun 28;222(5200):1291-2. doi: 10.1038/2221291a0.
9
The physico-chemical properties of cytophilic antibody.亲细胞抗体的物理化学性质。
Aust J Exp Biol Med Sci. 1968 Feb;46(1):73-81. doi: 10.1038/icb.1968.6.
10
Studies on cytophilic antibodies. 3. Sensitization of homologous and heterologous macrophages by cytophilic antibodies: inhibition of sensitization by normal serum.嗜细胞抗体研究。3. 嗜细胞抗体对同源和异源巨噬细胞的致敏作用：正常血清对致敏作用的抑制
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