针对载体的细胞介导免疫与载体-半抗原辅助效应之间缺乏相关性。
Lack of a correlation between cell-mediated immunity to the carrier and the carrier-hapten helper effect.
作者信息
Liew F Y, Parish C R
出版信息
J Exp Med. 1974 Mar 1;139(3):779-84. doi: 10.1084/jem.139.3.779.
Abstract
The relationship between cell-mediated immunity to the carrier and the carrier-hapten helper effect was studied in the rat by using three forms of the carrier which differed in their capacity to induce carrier-specific delayed-type hypersensitivity. The three carriers were polymerized flagellin (POL), flagellin (FIN), and acetoacetylated flagellin (AFIN), which induced FIN-specific delayed-type hypersensitivity in the order AFIN > FIN > POL. Helper cells for the anti-DNP antibody responses to a range of DNP-FIN conjugates appeared to be almost inversely related to cell-mediated immunity to the carrier, being in the order POL > FIN =/> AFIN. These differences occurred whether the carriers were injected in saline or FCA, but were less pronounced with the heavily DNP-conjugated flagellins.
摘要
通过使用三种诱导载体特异性迟发型超敏反应能力不同的载体形式，在大鼠中研究了针对载体的细胞介导免疫与载体-半抗原辅助效应之间的关系。这三种载体分别是聚合鞭毛蛋白（POL）、鞭毛蛋白（FIN）和乙酰乙酰化鞭毛蛋白（AFIN），它们诱导FIN特异性迟发型超敏反应的能力顺序为AFIN > FIN > POL。针对一系列DNP-FIN偶联物的抗DNP抗体反应的辅助细胞似乎与针对载体的细胞介导免疫几乎呈负相关，顺序为POL > FIN =/> AFIN。无论载体是注射在盐水中还是弗氏完全佐剂（FCA）中，都会出现这些差异，但对于高度DNP偶联的鞭毛蛋白，差异不太明显。
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