Maher J F, Hirszel P, Lasrich M
Kidney Int. 1979 Aug;16(2):130-6. doi: 10.1038/ki.1979.114.
Because the gastrointestinal hormones are known to dilate the splanchnic vasculature, their effects on transport of water and solutes during peritoneal dialysis were studied in an experimental model, the rabbit. In unanesthetized rabbits, dialysate volume was calculated by isotope dilution, and clearances were estimated by dialysate/plasma concentration ratio factored by minute volume. With isotonic dialysis solution, the mean increment in dialysate volume per minute of intraperitoneal dwell was 0.19 ml/kg/min, and mean clearances of creatinine and urea were 0.71 and 0.90 ml/kg/min, respectively. When administered intravenously, secretin significantly augmented osmotically induced water flux, but not when given intraperitoneally. Neither glucagon nor cholecystokinin affected dialysate volume. Intravenously, but not intraperitoneally, glucagon increased peritoneal clearances of creatinine and urea to more than 150% of control values. Neither cholecystokinin nor secretin augmented significantly peritoneal mass transport when given by either route. The data suggest that the site of acton is the endothelial surface of the membrane, that the mechanisms of augmenting transport involve increased permeability and/or surface area, and that agents which combine an increase in mass transport and capillary filtration coefficient may be clinically useful.
由于已知胃肠激素可扩张内脏血管系统，因此在兔这一实验模型中研究了它们对腹膜透析期间水和溶质转运的影响。在未麻醉的兔中，通过同位素稀释计算透析液体积，并通过透析液/血浆浓度比乘以分钟体积来估算清除率。使用等渗透析液时，腹膜内停留每分钟透析液体积的平均增加量为0.19 ml/kg/min，肌酐和尿素的平均清除率分别为0.71和0.90 ml/kg/min。静脉注射促胰液素可显著增加渗透诱导的水通量，但腹膜内注射时则无此作用。胰高血糖素和胆囊收缩素均不影响透析液体积。静脉注射而非腹膜内注射时，胰高血糖素可使肌酐和尿素的腹膜清除率增加至对照值的150%以上。无论通过何种途径给药，胆囊收缩素和促胰液素均未显著增加腹膜物质转运。数据表明，作用部位是膜的内皮表面，增加转运的机制涉及通透性增加和/或表面积增加，并且结合物质转运增加和毛细血管滤过系数增加的药物可能具有临床应用价值。
