Maher J F
Artif Organs. 1979 Aug;3(3):224-7. doi: 10.1111/j.1525-1594.1979.tb01052.x.
The major restrictions to the transport of solute and solvent across the peritoneum are the limited peritoneal blood flow, area and permeability. Recent investigations have demonstrated that several vasoactive drugs influence transport parameters. Isoproterenol, nitroprusside, dipyridamole and dopamine exemplify drugs that dilate the splanchnic vasculature, thereby augmenting transport, whereas vasoconstriction induced by l-norepinephrine decreases clearances. The tissue prostaglandins affect peritoneal mass transport in accord with their known vasoactive effects, suggesting a role in modulating peritoneal blood flow. The gastrointestinal hormones vasodilate the splanchnic circulation. Exposure of the endothelial surface to glucagon markedly increases peritoneal mass transport, while secretin increases the ultrafiltration rate significantly. These preliminary studies suggest the possible future clinical use of drugs and hormones to augment the efficiency of peritoneal dialysis.
溶质和溶剂通过腹膜转运的主要限制因素是腹膜血流有限、面积和通透性。最近的研究表明，几种血管活性药物会影响转运参数。异丙肾上腺素、硝普钠、双嘧达莫和多巴胺是扩张内脏血管系统从而增加转运的药物的代表，而左旋去甲肾上腺素引起的血管收缩则会降低清除率。组织前列腺素根据其已知的血管活性作用影响腹膜物质转运，提示其在调节腹膜血流中发挥作用。胃肠激素可使内脏循环血管舒张。内皮表面暴露于胰高血糖素会显著增加腹膜物质转运，而促胰液素会显著提高超滤率。这些初步研究表明，药物和激素未来可能在临床上用于提高腹膜透析的效率。
