Hirszel P, Maher J F, Chamberlin M
J Dial. 1978;2(2):131-42. doi: 10.3109/08860227809079313.
Lightly restrained, alert New Zealand white rabbits underwent peritoneal dialysis by percutaneous instillation of standard dialysis solution with or without intraperitoneal nitroprusside. Corrected to a mean intraperitoneal dwell time of 36 minutes, mean clearances of creatinine and urea were 0.74 and 0.90 ml/kg/min in six rabbits. With intraperitoneal nitroprusside, 1.13 mg/kg clearances increased to 1.13 and 1.30 ml/kg/min (p less than 0.01) respectively. The 53% increment in creatinine clearance maintained the ratio clearance larger/smaller solute suggesting increased peritoneal permeability and/or area. Lower nitroprusside doses were less effective and not significantly above control. Nitroprusside also increased clearances during hypertonic peritoneal dialysis, but had no effect on osmotically induced water flux. Lavage studies demonstrated a persistent effect of nitroprusside after a single exposure and a sustained effect with repeated use.
将轻度约束、警觉的新西兰白兔经皮注入标准透析液进行腹膜透析，透析液中添加或不添加腹腔内硝普钠。校正后的平均腹腔停留时间为36分钟，6只兔子的肌酐和尿素平均清除率分别为0.74和0.90 ml/kg/分钟。腹腔内使用硝普钠，剂量为1.13 mg/kg时，清除率分别增加到1.13和1.30 ml/kg/分钟（p小于0.01）。肌酐清除率增加53%，维持了较大/较小溶质清除率的比值，提示腹膜通透性和/或面积增加。较低剂量的硝普钠效果较差，且与对照组相比无显著差异。硝普钠在高渗腹膜透析期间也增加了清除率，但对渗透诱导的水通量没有影响。灌洗研究表明，单次暴露后硝普钠有持续作用，重复使用有持续效果。
