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[二硫化碳慢性吸入中毒对家兔血清、主动脉及心肌中各种脂质代谢指标含量的影响。II. 血清、主动脉及心肌中的脂质磷和磷脂组分]

[Effects of chronic inhalation intoxication with carbon disulfide on the content of various lipid metabolism indices in the serum, aorta and cardiac muscle in rabbits. II. Lipid phosphorus and phospholipid fractions in the serum, aorta and cardiac muscle].

作者信息

Wesołowska T

出版信息

Med Pr. 1979;30(5):323-30.

PMID:514068
Abstract

Lipid phosphorus and single phospholipids content was checked in serum, aorta and cardiac muscle of rabbits exposed in toxicological chamber for 3 and 6 months, to carbon disulfide of low concentration (0.44 mg/l) and higher concentration (0.8 mg/l). Phospholipids were separated using thin--layer chromatography. Lipid phosphorus content in each fraction was determined colorimetrically. Statistical analysis of obtained results was done based on the Student "t" test. Lipid phosphorus content in serum, aorta and cardiac muscle was found to increase in animals exposed to CS2 in lower concentration. A decrease in lipid phosphorus content (statistically significant) was noted in the serum of rabbits intoxicated with CS2 in high concentration for 3 months. Changes in the percentage of phosphatidylcholine and sphingomyelins in cardiac muscle were found.

摘要

对在毒理学舱中暴露于低浓度(0.44毫克/升)和高浓度(0.8毫克/升)二硫化碳3个月和6个月的家兔的血清、主动脉和心肌中的脂质磷和单一磷脂含量进行了检测。使用薄层色谱法分离磷脂。用比色法测定各组分中的脂质磷含量。基于学生“t”检验对所得结果进行统计分析。发现暴露于较低浓度二硫化碳的动物血清、主动脉和心肌中的脂质磷含量增加。在高浓度二硫化碳中毒3个月的家兔血清中,脂质磷含量出现下降(具有统计学意义)。还发现心肌中磷脂酰胆碱和鞘磷脂的百分比发生了变化。

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