Sutherland G R, Hume R, James W B, Davison M, Kennedy J
Thorax. 1971 Nov;26(6):716-20. doi: 10.1136/thx.26.6.716.
In 20 male patients suffering from chronic bronchitis and emphysema investigated by pulmonary -ray densitometry, five different types of densitometer trace pattern were observed during the FEV manoeuvre, which appeared to be related to the degree of zonal airway obstruction and the radiological severity of emphysema. We thought some of the features of the traces were caused by displacement of blood from the area of the lung being examined by trapped alveolar air at a pressure exceeding those in the surrounding blood vessels. A close correlation (P<0·001) was found between the conventional FEV and the pulmonary densitometer score derived from summated regional observations made during the FEV manoeuvre. A similar high degree of correlation was observed between the FEV and a score based on regional radiological appearances. Correlations between Pao and Paco and the densitometer and -ray scores were of doubtful significance. The findings indicate that critical evaluation of the radiological features of the pulmonary vessels in patients with emphysema is useful in assessing the overall degree of airway obstruction. Regional densitometer pattern analysis is a valuable contributory method of investigating these patients and the results of a comparison of these two methods suggest that it may be possible to distinguish between larger and smaller airway obstruction.
对20例慢性支气管炎和肺气肿男性患者进行肺部射线密度测定研究，在用力呼气容积（FEV）操作过程中观察到五种不同类型的密度计轨迹模式，这些模式似乎与局部气道阻塞程度和肺气肿的放射学严重程度有关。我们认为，这些轨迹的一些特征是由于在高于周围血管压力的情况下，被困肺泡气将血液从被检查的肺区域置换出来所致。在常规FEV与用力呼气容积操作过程中进行的区域观察总和得出的肺部密度计评分之间发现了密切相关性（P<0·001）。在FEV与基于局部放射学表现的评分之间也观察到了类似的高度相关性。动脉血氧分压（Pao）和动脉血二氧化碳分压（Paco）与密度计及射线评分之间的相关性意义存疑。这些发现表明，对肺气肿患者肺部血管的放射学特征进行批判性评估有助于评估气道阻塞的总体程度。区域密度计模式分析是研究这些患者的一种有价值的辅助方法，这两种方法的比较结果表明，有可能区分较大和较小气道的阻塞情况。
