新生霉素对腺病毒DNA合成和衣壳化的影响。
Effects of novobiocin on adenovirus DNA synthesis and encapsidation.
作者信息
D'Halluin J C, Milleville M, Boulanger P
出版信息
Nucleic Acids Res. 1980 Apr 11;8(7):1625-41. doi: 10.1093/nar/8.7.1625.
Abstract
Novobiocin, an inhibitor of DNA gyrase implicated in bacterial and likely mammalian, chromosome replication, inhibited the initiation, but not the elongation of human adenovirus DNA replicative synthesis. The inhibition was partially reversible, even in the presence of protein synthesis inhibitor. Novobiocin inhibited also the encapsidation of viral DNA, and this effect was independent of the block in DNA replication. It was suggested that novobiocin acted on two different functions, one involved in viral DNA replication initiation, the other in DNA encapsidation.
摘要
新生霉素是一种参与细菌及可能的哺乳动物染色体复制的DNA促旋酶抑制剂，它抑制人腺病毒DNA复制性合成的起始，但不抑制其延伸。即使存在蛋白质合成抑制剂，这种抑制作用也部分可逆。新生霉素还抑制病毒DNA的包装，且这种效应与DNA复制受阻无关。有人提出新生霉素作用于两种不同功能，一种参与病毒DNA复制起始，另一种参与DNA包装。
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