肺炎支原体与溶神经支原体脂质之间的血清学交叉反应。
Serological cross-reaction between lipids of Mycoplasma pneumoniae and Mycoplasma neurolyticum.
作者信息
Kenny G E
出版信息
Infect Immun. 1971 Aug;4(2):149-53. doi: 10.1128/iai.4.2.149-153.1971.
The complement-fixing activity of crude lipid extracts of 10 Mycoplasma species was compared with that of whole organism antigens employing immune rabbit serum. Five species (M. pneumoniae, M. neurolyticum, M. granularum, M. laidlawii, and M. fermentans) showed serological activity, whereas the remaining five species (M. canis, M. felis, M. gallisepticum, M. hyorhinis, and M. pulmonis) did not show significant activity in their lipid fractions. The lipid fractions of the five species which had serological activity in their lipid fractions showed three groups of serological specificity. M. pneumoniae cross-reacted with M. neurolyticum, M. granularum cross-reacted with M. laidlawii, and M. fermentans showed specific activity. Acute and convalescent sera from human pneumonia patients from whom M. pneumoniae had been isolated showed antibody increases which could be measured nearly as well by lipids of M. neurolyticum as by those of M. pneumoniae. Only a few human convalescent sera showed antibody measureable by lipids of M. granularum, M. pneumoniae did not cross-react with M. neurolyticum by other serological parameters such as growth inhibition on agar or double immunodiffusion, indicating that only the lipid antigens of these two species cross-react.
利用免疫兔血清，比较了10种支原体粗脂质提取物与全菌体抗原的补体结合活性。5种支原体（肺炎支原体、溶神经支原体、颗粒支原体、莱氏无胆甾原体和发酵支原体）表现出血清学活性，而其余5种支原体（犬支原体、猫支原体、鸡毒支原体、猪鼻支原体和肺支原体）的脂质部分未表现出显著活性。脂质部分具有血清学活性的5种支原体的脂质部分表现出三组血清学特异性。肺炎支原体与溶神经支原体发生交叉反应，颗粒支原体与莱氏无胆甾原体发生交叉反应，发酵支原体表现出特异性活性。从分离出肺炎支原体的人类肺炎患者获得的急性期和恢复期血清显示抗体增加，用溶神经支原体的脂质检测抗体增加的效果几乎与用肺炎支原体的脂质检测相同。只有少数人类恢复期血清能用颗粒支原体的脂质检测到抗体，肺炎支原体与溶神经支原体在其他血清学参数（如琼脂上的生长抑制或双向免疫扩散）方面不发生交叉反应，这表明只有这两种支原体的脂质抗原发生交叉反应。
Zotero 插件