Pike R M, Chandler C H
Infect Immun. 1971 Nov;4(5):589-92. doi: 10.1128/iai.4.5.589-592.1971.
Fractions of rabbit anti-Vibrio cholerae serum containing gammaG antibodies were compared with fractions containing gammaM antibodies for their ability to protect mice against lethal infection resulting from the intraperitoneal injection of organisms suspended in mucin. About twice as much gammaG as gammaM (estimated by quantitative precipitation) was required to protect against approximately 1,000 50% lethal doses when the antibody was given intraperitoneally 4 hr before challenge. When protective serum fractions were given subcutaneously, however, the amount of gammaM required to protect was increased about 40-fold, whereas gammaG was about equally effective subcutaneously and intraperitoneally.
将含有γG抗体的兔抗霍乱弧菌血清组分与含有γM抗体的组分进行比较，观察它们保护小鼠抵抗腹腔注射黏蛋白悬液中霍乱弧菌所致致死性感染的能力。当在攻击前4小时腹腔注射抗体时，保护小鼠抵抗约1000个50%致死剂量所需的γG约为γM的两倍（通过定量沉淀法估算）。然而，当皮下注射保护性血清组分时，保护所需的γM量增加约40倍，而γG皮下注射和腹腔注射的效果大致相同。
