Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida 32601.
Infect Immun. 1971 Jan;3(1):154-8. doi: 10.1128/iai.3.1.154-158.1971.
Purified IgM and IgG antibodies to Salmonella typhimurium "O" antigen were prepared from rabbit serum collected "early" (6 to 8 days) and "late" (30 to 32 days) during the course of the immune response. The effect which these passively administered antibodies had upon the reticuloendothelial organ sequestration of intravenously injected (125)I-labeled heat-killed S. typhimurium in nonimmune rabbits was studied. In the absence of specific antibody, the spleen (per gram) sequestered more organisms than did the liver, kidneys, and lungs. In the presence of "early" antibody to S. typhimurium, sequestration of organisms in the spleen was two to three times greater than sequestration in the spleen of animals that had received "late" antibody to S. typhimurium, heterologous antibody or no antibody. Although "late" antibody did not increase sequestration of organisms in the spleen, it did result in a per gram liver sequestration of bacteria which was two times greater than that observed in animals that had received "early" antibodies to S. typhimurium, heterologous antibody or no antibody. The presence of passively administered antibody had no detectable effect upon the sequestration of bacteria in the kidneys and the lungs. Thus, it would seem that antibodies isolated early in the immune response increase the efficiency of splenic sequestration of blood-borne particulate material, whereas "late" antibody favors sequestration in the liver.
从感染过程中“早期”（6 到 8 天）和“晚期”（30 到 32 天）收集的兔血清中制备出针对鼠伤寒沙门氏菌“O”抗原的纯化 IgM 和 IgG 抗体。研究了这些被动给予的抗体对非免疫兔静脉注射（125）I 标记的热灭活鼠伤寒沙门氏菌在网状内皮器官中的隔离作用。在没有特异性抗体的情况下，脾脏（每克）隔离的生物体比肝脏、肾脏和肺部多。在存在针对鼠伤寒沙门氏菌的“早期”抗体的情况下，脾脏中生物体的隔离量是接受鼠伤寒沙门氏菌的“晚期”抗体、异种抗体或无抗体的动物脾脏中隔离量的两到三倍。尽管“晚期”抗体不会增加脾脏中生物体的隔离量，但它导致每克肝脏中细菌的隔离量是接受鼠伤寒沙门氏菌的“早期”抗体、异种抗体或无抗体的动物的两倍。被动给予的抗体对肾脏和肺部中细菌的隔离没有明显影响。因此，似乎在免疫反应早期分离出的抗体可提高脾脏对血液传播颗粒物质的隔离效率，而“晚期”抗体则有利于肝脏的隔离。
