小鼠对霍乱弧菌的免疫力。II. 细胞黏附免疫因子的作用。
Immunity to Vibrio cholerae in the mouse. II. Effect of a cell-adherent immune factor.
作者信息
Actor P, Pitkin D
出版信息
Infect Immun. 1973 Jan;7(1):35-8. doi: 10.1128/iai.7.1.35-38.1973.
Abstract
Serum, peritoneal exudate cells, or spleen cells were obtained from donor mice immunized with Vibrio cholerae Ogawa 41. Normal recipients were protected from lethal Vibrio infection when challenged one day after transfer of immune serum or peritoneal cells or normal peritoneal cells exposed in vitro to immune serum. Protection of recipients of immune spleen cells was evident when the cell transfer-challenge interval was 14 days but not when it was 1 day. Transfer of immunity with peritoneal cells from actively immunized donors was long lasting, whereas that derived from in vitro treatment of normal cells was of short duration. Both a cell-adherent and a nonadhering immune factor appear to be important in this immunity.
摘要
血清、腹腔渗出细胞或脾细胞取自用小川型霍乱弧菌41免疫的供体小鼠。当在输注免疫血清或腹腔细胞或体外暴露于免疫血清的正常腹腔细胞一天后进行攻击时，正常受体可免受致死性弧菌感染。当细胞转移 - 攻击间隔为14天时，免疫脾细胞受体的保护作用明显，但间隔为1天时则不明显。来自主动免疫供体的腹腔细胞的免疫转移持续时间长，而来自正常细胞体外处理的免疫转移持续时间短。一种细胞粘附性和一种非粘附性免疫因子在这种免疫中似乎都很重要。
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