甘氨酸在大鼠大脑皮层切片中的摄取与流出
The uptake and efflux of glycine from rat cerebral-cortex slices.
作者信息
Joanny P, Barbosa E, Hillman H, Corriol J
出版信息
Biochem J. 1971 Nov;125(1):255-60. doi: 10.1042/bj1250255.
Abstract
The kinetics of the influx and efflux of radioactive l-glycine was studied in slices of rat cerebral cortex. The influx showed saturation kinetics and was inhibited by l-alanine. Influx was dependent on the presence of Na(+) ions and a metabolizable substrate. The efflux of glycine was accelerated by alanine. It was concluded that carrier-mediated facilitated diffusion was the mechanism of glycine uptake by, and efflux from, cerebral slices.
摘要
在大鼠大脑皮层切片中研究了放射性L-甘氨酸的流入和流出动力学。流入表现出饱和动力学，并受到L-丙氨酸的抑制。流入依赖于Na(+)离子和可代谢底物的存在。丙氨酸加速了甘氨酸的流出。得出的结论是，载体介导的易化扩散是大脑切片摄取和流出甘氨酸的机制。
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