[Content of biological oxidation metabolites in the blood and urine of peptic ulcer patients].

Content of pyruvic, lactic, citric, acetic, oxaloacetic acids in blood as well as excretion of pyruvic acid with urine were studied in patients with ulcer, chronic gastritis, carcinoma of the stomach and in healthy persons. Concentrations of pyruvic and lactic acids in blood as well as excretion of pyruvic acid with urine were increased in the patients during acute periods of ulcerous disease, chronic gastritis and in carcinoma of the stomach. Level of citric acid was decreased in blood in ulcerous disease and increased in chronic gastritis and, especially, in the carcinoma. During acute period of ulcerous disease concentration of acetic acid was decreased in blood. Content of oxaloacetic acid was similar both in healthy persons and in patients with the disease. The data obtained suggest that oxidative decarboxylation of pyruvic acid is inhibited in patients with ulcerous disease.