Balitskii K P, Sopotsinskaia E B
Vopr Onkol. 1979;25(12):30-6.
Blood fibrin being deposited around the circulating tumor cells seems to contribute to metastatic spread, thus enhancing the cell implantation. Whereas the same fibrin hampers cells detachment from a tumor node and their further dissemination in the organism. The anticoagulation blood system interfers with the fibrin formation, whereby inhibiting the cell implantation and metastatic spread, but is may also enhance them, contributing to detachment and dissemination of tumor cells. In this respect, to enhance the antimetastatic resistance of the body there must be a balanced interaction between the coagulation and anticoagulation blood systems with an unremoved tumor and the increased anticoagulation function after the tumor node resection especially in the early postoperative period.
循环肿瘤细胞周围沉积的血纤维蛋白似乎有助于转移扩散，从而增强细胞植入。而同样的纤维蛋白会阻碍细胞从肿瘤结节脱离及其在体内的进一步播散。抗凝血液系统干扰纤维蛋白的形成，从而抑制细胞植入和转移扩散，但也可能增强它们，促进肿瘤细胞的脱离和播散。在这方面，为增强机体的抗转移能力，在存在未切除肿瘤的情况下，凝血和抗凝血液系统之间必须有平衡的相互作用，且在肿瘤结节切除后，尤其是术后早期，抗凝功能要增强。
