土霉素对青霉素酶诱导的优先抑制作用及其对葡萄球菌青霉素敏感性的影响。
Preferential inhibition of penicillinase induction by oxytetracycline and its effect on the penicillin susceptibility of staphylococci.
作者信息
Michael T M, Michael J G, Massell B F
出版信息
J Bacteriol. 1967 Jun;93(6):1749-52. doi: 10.1128/jb.93.6.1749-1752.1967.
Abstract
Exposure of penicillinase-producing staphylococci to a combination of penicillin and oxytetracycline resulted in a synergistic inhibitory activity of the antibiotics on the bacteria. Oxytetracycline was employed in concentrations having little or no effect on bacterial growth. It was found that the synergistic antibacterial effect was caused by the preferential inhibition of penicillinase induction by oxytetracycline, rendering the staphylococci more susceptible to penicillin.
摘要
产青霉素酶葡萄球菌暴露于青霉素和土霉素的组合中，会导致这两种抗生素对该细菌产生协同抑制活性。所使用的土霉素浓度对细菌生长几乎没有影响或完全没有影响。结果发现，这种协同抗菌作用是由于土霉素优先抑制了青霉素酶的诱导，从而使葡萄球菌对青霉素更敏感。
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