氯霉素诱导抑制葡萄球菌青霉素酶产生的杀菌协同效应。
Bactericidal synergistic effect due to chloramphenicol-induced inhibition of staphyloccal penicillinase.
作者信息
Michel J, Jacobs J, Sacks T
出版信息
Chemotherapy. 1977;23(1):32-6. doi: 10.1159/000221968.
PMID:832531
Abstract
A synergistic bactericidal effect of chloramphenicol and penicillin-G was observed with 17 out of 20 beta-lactamase producing strains of Staphylococcus aureus. The synergism was due to chloramphenicol-induced inhibition of beta-lactamase production. With seven of the strains the synergistic effect was operative only with subinhibitory concentrations of chloramphenicol, while higher concentrations produced antagonism.
摘要
在20株产β-内酰胺酶的金黄色葡萄球菌菌株中，观察到17株氯霉素和青霉素G具有协同杀菌作用。这种协同作用是由于氯霉素诱导抑制β-内酰胺酶的产生。对于其中7株菌株，协同作用仅在亚抑制浓度的氯霉素时起作用，而较高浓度则产生拮抗作用。
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