青霉素-红霉素对耐抗生素金黄色葡萄球菌协同作用的机制
Mechanism of penicillin-erythromycin synergy on antibiotic-resistant Staphylococcus aureus.
作者信息
Allen N E, Epp J K
出版信息
Antimicrob Agents Chemother. 1978 May;13(5):849-53. doi: 10.1128/AAC.13.5.849.
Abstract
Clinically isolated strains of Staphylococcus aureus that are inducibly resistant to both erythromycin and penicillin were susceptible to a combination of the two antibiotics. The synergistic effect of the combination results from an inhibition of penicillinase induction by erythromycin, sparing penicillin and allowing this drug to inhibit growth. When resistance to erythromycin is constitutive rather than inducible, the combination is no longer synergistic.
摘要
对红霉素和青霉素均呈诱导性耐药的临床分离金黄色葡萄球菌菌株，对这两种抗生素的联合使用敏感。该联合用药的协同效应源于红霉素对青霉素酶诱导的抑制作用，使青霉素得以保留并发挥抑菌作用。当对红霉素的耐药性为固有性而非诱导性时，联合用药不再具有协同作用。
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本文引用的文献
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Apparent synergy between penicillin and erythromycin or fusidic acid.青霉素与红霉素或夫西地酸之间存在明显协同作用。
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Antagonism between antibacterial drugs.抗菌药物之间的拮抗作用。
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Erythrocillin: a new approach to the problem of antibiotic-resistant staphylococci.红霉素：解决耐抗生素葡萄球菌问题的新方法。
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Gratuitous synthesis of beta-lactamase in Staphylococcus aureus.金黄色葡萄球菌中β-内酰胺酶的无端合成。
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Altered methylation of ribosomal RNA in an erythromycin-resistant strain of Staphylococcus aureus.耐红霉素金黄色葡萄球菌菌株中核糖体RNA甲基化的改变
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