Gabrielian E S, Amroian E A, Aĭvazian A G
Biull Eksp Biol Med. 1979 Sep;88(9):309-11.
A marked increase in the prostaglandin E (PGE) content in the cerebrospinal fluid (CSF) and the arterial blood of cats was observed under conditions of 3-minute hypocapnia. During 30-minute hypocapnia a restoration of the initial PGE level was seen. The PGE content in CSF increased while in the arterial blood it decreased comparatively to the control under conditions of 3-minute hypercapnia. In 30-minute hypercapnia the PGE amount in the CSF and the blood dropped in comparison with 3-minute hypercapnia being below the basal level in the blood. It is suggested that in hypocapnia PGE should limit its constrictive effect on the cerebral vessels while under conditions of hypercapnia they are to promote the realization of the cerebral vessel reaction to CO2.
在猫出现3分钟低碳酸血症的情况下，观察到其脑脊液（CSF）和动脉血中前列腺素E（PGE）含量显著增加。在30分钟低碳酸血症期间，可见PGE水平恢复至初始水平。在3分钟高碳酸血症的情况下，CSF中的PGE含量增加，而动脉血中的PGE含量相对于对照组则下降。在30分钟高碳酸血症时，CSF和血液中的PGE量与3分钟高碳酸血症相比有所下降，血液中的PGE量低于基础水平。有人提出，在低碳酸血症时，PGE应限制其对脑血管的收缩作用，而在高碳酸血症情况下，它们应促进脑血管对二氧化碳反应的实现。
