McMahon J E, Kolstrup N
Br Med J. 1979 Dec 1;2(6202):1396-9. doi: 10.1136/bmj.2.6202.1396.
The effectiveness of the new schistosomicide praziquantel was assessed in African schoolchildren infected with Schistosoma haematobium. They were stratified according to the severity of their infection and were then randomly allocated to treatment with two single-dose regimens (30 and 40 mg/kg) and a split regimen of two doses of 20 mg/kg given four hours apart. All three regimens were highly effective and produced few side effects. Children who initially had very high pretreatment egg loads showed a poorer therapeutic response at all dose levels, and further investigations are necessary to find the optimum dose. Because of its effectiveness in a single dose and lack of toxicity, praziquantel may prove to be the ideal schistosomicide.
新型抗血吸虫药吡喹酮在感染埃及血吸虫的非洲学童中进行了疗效评估。根据感染严重程度将他们分层，然后随机分配接受两种单剂量方案（30和40毫克/千克）以及一种分两次给药、每次20毫克/千克、间隔4小时的方案治疗。所有三种方案都非常有效且副作用少。最初预处理时虫卵负荷非常高的儿童在所有剂量水平下的治疗反应都较差，因此有必要进一步研究以找到最佳剂量。由于吡喹酮单剂量有效且无毒，它可能被证明是理想的抗血吸虫药。
