切口内头孢菌素：两种给药方法的比较
Intra-incisional cephaloridine: a comparison of two methods of administration.
作者信息
Ball A J, Foster M E, Evans P J
出版信息
Curr Med Res Opin. 1979;6(3):204-6. doi: 10.1185/03007997909109422.
PMID:520026
Abstract
Serum cephaloridine concentrations were measured in the immediate post-operative period in 23 patients who had received a prophylactic dose of 1 g of the drug into the wound at the end of operation. Eleven patients received the antibiotic as a powder and 12 as a solution. The serum concentrations were higher, though not significantly so, in the group receiving powder, and this is thought to be due to the lesser amount of spillage and loss into dressings when the antibiotic is given in this form.
摘要
对23例患者在术后即刻测定了血清头孢噻啶浓度，这些患者在手术结束时已在伤口给予1克该药的预防剂量。11例患者接受的抗生素为粉末状，12例接受的是溶液状。接受粉末状抗生素的组血清浓度较高，尽管差异无统计学意义，这被认为是由于以这种形式给予抗生素时，其溢出和渗入敷料的量较少。
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