五种新的99mTc-HIDA异构体的合成及其与99mTc-HIDA的比较。
Synthesis of five new 99mTc-HIDA isomers and comparison with 99mTc-HIDA.
作者信息
van Wyk A J, Fourie P J, van Zyl W H, Lötter M G, Minnaar P C
出版信息
Eur J Nucl Med. 1979 Dec;4(6):445-8. doi: 10.1007/BF00300843.
PMID:520359
Abstract
Five new HIDA-compounds were synthesized, labelled with 99mTc and compared with 99mTc-(2,6-dimethyl)HIDA viz. (N-2,6-dimethylphenylcarbamoylmethyl)iminodiacetic acid by means of TLC and biodistribution studies on rabbits. The computerized method used by Britton and Brown during renal studies was successfully adapted to study the biodistribution of these agents.
摘要
合成了五种新的HIDA化合物，用99mTc进行标记，并通过薄层色谱法（TLC）和对兔子的生物分布研究，与99mTc-(2,6-二甲基)HIDA即（N-2,6-二甲基苯基氨基甲酰甲基）亚氨基二乙酸进行比较。布里顿和布朗在肾脏研究中使用的计算机化方法成功地用于研究这些药剂的生物分布。
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