末端半缩醛基团对尼日利亚菌素离子载体特性的重要性。
The importance of the terminal hemi-acetal group for the ionophoric properties of nigericin.
作者信息
David L, Chapel M, Gandreuil J, Jeminet G, Durand R
出版信息
Experientia. 1979 Dec 15;35(12):1562-3. doi: 10.1007/BF01953193.
PMID:520454
Abstract
Opening of the terminal hemi-acetal in dihydronigericin drastically reduces the ionophoric properties of nigericin and dehydroxymethylnigericin with 6 intact heterocycles. This is shown by 2 complementary methods, first with a liquid membrane electrode system, secondly by testing their ionophoric activities in rat liver mitochondria.
摘要
二氢尼日利亚菌素中末端半缩醛的开放极大地降低了尼日利亚菌素和具有6个完整杂环的去氧甲基尼日利亚菌素的离子载体特性。这通过两种互补方法得以证明，第一种是使用液膜电极系统，第二种是在大鼠肝线粒体中测试它们的离子载体活性。
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本文引用的文献
1
The structure of nigericin.尼日利亚菌素的结构。
Biochem Biophys Res Commun. 1968 Oct 10;33(1):29-31. doi: 10.1016/0006-291x(68)90249-0.
2
[Alkali-cation specificity and carrier qualities of the antibiotics nigericin and monensin].[抗生素尼日利亚菌素和莫能菌素的碱阳离子特异性及载体性质]
Helv Chim Acta. 1970;53(7):1741-6. doi: 10.1002/hlca.19700530723.
3
The crystal structure of the potassium salt of nigericin.尼日利亚菌素钾盐的晶体结构。
Biochem Biophys Res Commun. 1974 Oct 23;60(4):1245-51. doi: 10.1016/0006-291x(74)90332-5.
4
Polyether antibiotics: versatile carboxylic acid ionophores produced by Streptomyces.聚醚抗生素：由链霉菌产生的多功能羧酸离子载体。
Adv Appl Microbiol. 1977;22:177-223. doi: 10.1016/s0065-2164(08)70163-1.
5
The influence of pH on the conductance of lipid bimolecular membranes in relation to the alkaline ion transport induced by carboxylic carriers grisorixin, alborixin and monensin.pH对脂质双分子膜电导的影响与羧酸载体格利索菌素、白僵菌素和莫能菌素诱导的碱性离子转运的关系。
Biochim Biophys Acta. 1978 Aug 17;511(3):499-508. doi: 10.1016/0005-2736(78)90284-5.
6
Effects of grisorixin on glutamate transport and oxidation in rat liver mitochondria. Relationships between transport and oxidation.灰黄霉素对大鼠肝线粒体中谷氨酸转运和氧化的影响。转运与氧化之间的关系。
Biochimie. 1977;59(5-6):497-508. doi: 10.1016/s0300-9084(77)80055-2.
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