末端半缩醛基团对尼日利亚菌素离子载体特性的重要性。
The importance of the terminal hemi-acetal group for the ionophoric properties of nigericin.
作者信息
David L, Chapel M, Gandreuil J, Jeminet G, Durand R
出版信息
Experientia. 1979 Dec 15;35(12):1562-3. doi: 10.1007/BF01953193.
PMID:520454
Abstract
Opening of the terminal hemi-acetal in dihydronigericin drastically reduces the ionophoric properties of nigericin and dehydroxymethylnigericin with 6 intact heterocycles. This is shown by 2 complementary methods, first with a liquid membrane electrode system, secondly by testing their ionophoric activities in rat liver mitochondria.
摘要
二氢尼日利亚菌素中末端半缩醛的开放极大地降低了尼日利亚菌素和具有6个完整杂环的去氧甲基尼日利亚菌素的离子载体特性。这通过两种互补方法得以证明，第一种是使用液膜电极系统，第二种是在大鼠肝线粒体中测试它们的离子载体活性。
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