Zier K S, Bach F H
Scand J Immunol. 1975 Sep;4(5-6):607-11. doi: 10.1111/j.1365-3083.1975.tb02667.x.
The secondary response of human lymphocytes following restimulation with alloantigens has been studied. If fresh stimulating cells are added to a mixed leukocyte culture (MLC) at a time when the peak of proliferative and cytotoxic activity has passed, a rapid reactivation occurs. The secondary response in MLC demonstrates specificity such that restimulation with the original sensitizing cell (or one presumably sharing the LD genetic determinants responsible for triggering MLC) induces a greater proliferative response than a third-party cell. On the other hand, the secondary cytotoxic response is directed towards the SD antigens of the original sensitizing cell regardless of which cell is used for restimulation. Possible mechanisms of cellular interactions are considered to explain these results.
对人类淋巴细胞在同种异体抗原再次刺激后的二次反应进行了研究。如果在增殖和细胞毒性活性达到峰值后，将新鲜的刺激细胞添加到混合淋巴细胞培养物（MLC）中，会发生快速再激活。MLC中的二次反应表现出特异性，即与原始致敏细胞（或假定共享负责触发MLC的LD遗传决定簇的细胞）再次刺激相比，用第三方细胞刺激会诱导更大的增殖反应。另一方面，二次细胞毒性反应针对原始致敏细胞的SD抗原，而不管使用哪种细胞进行再刺激。考虑了细胞相互作用的可能机制来解释这些结果。
