Hynes R O, Destree A T, Perkins M E, Wagner D D
J Supramol Struct. 1979;11(1):95-104. doi: 10.1002/jss.400110110.
Fibronectin is a large glycoprotein at the cell surface of many different cell types; a related protein is present in plasma. Fibronectin is a dimer of 230,000-dalton subunits and also occurs in larger aggregates; it forms fibrillar networks at the cell surface, between cells and substrata and between adjacent cells, and it is not a typical membrane protein. Cell surface fibronectin is reduced in amount or absent on transformed cells and in many cases its loss correlates with acquisition of tumorigenicity and, in particular, metastatic ability. Exceptions to the correlations with transformation and tumorigenicity exist. Loss of fibronectin and the resulting reduced adhesion appear to be involved in pleiotropic alterations in cell behavior and may be responsible for several aspects of the transformed phenotype in vitro. Fibronectin interacts with other macromolecules (collagen/gelatin, fibrin/fibrinogen, proteoglycans) and is apparently connected to microfilaments inside the cell.
纤连蛋白是多种不同细胞类型细胞表面的一种大型糖蛋白；血浆中也存在一种相关蛋白。纤连蛋白是由230,000道尔顿亚基组成的二聚体，也以更大的聚集体形式存在；它在细胞表面、细胞与基质之间以及相邻细胞之间形成纤维状网络，且它不是典型的膜蛋白。转化细胞表面的纤连蛋白数量减少或缺失，在许多情况下，其缺失与致瘤性尤其是转移能力的获得相关。与转化和致瘤性的相关性也有例外情况。纤连蛋白的缺失以及由此导致的黏附力降低似乎参与了细胞行为的多效性改变，可能是体外转化表型多个方面的原因。纤连蛋白与其他大分子（胶原蛋白/明胶、纤维蛋白/纤维蛋白原、蛋白聚糖）相互作用，并且显然与细胞内的微丝相连。
