萘和苯并(a)芘在大鼠空肠原位的吸收与代谢
Absorption and metabolism of naphthalene and benzo(a)pyrene in the rat jejunum in situ.
作者信息
Bock K W, von Clausbruch U C, Winne D
出版信息
Med Biol. 1979 Oct;57(5):262-4.
PMID:522514
Abstract
Naphthalene or benzo(a)pyrene (100 nmol) was instilled into the closed rat intestinal loop in situ and the appearance of the free compound and its metabolites was determined in portal blood. Naphthalene appeared mostly unchanged in blood whereas benzo(a)pyrene was extensively metabolized by mucosal cells. The results suggest that absorption and metabolism are competing processes in the gut.
摘要
将萘或苯并(a)芘（100纳摩尔）原位注入封闭的大鼠肠袢，测定门静脉血中游离化合物及其代谢产物的出现情况。萘在血液中大多保持不变，而苯并(a)芘则被粘膜细胞广泛代谢。结果表明，吸收和代谢是肠道中的竞争过程。
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