Remy W, Bockendahl H, Stüttgen G
Acta Derm Venereol. 1975;55(4):313-5.
Two patients with bullous pemphigoid were treated with radio cobalt or betatron irradiation. Thereafter bullous eruptions developed in the non-irradiated skin. It is known from the literature that ultraviolet light applied to the normal-appearing skin of patients with bullous pemphigoid produced fresh histologic and immunohistochemical changes in the irradiated skin. X-ray irradiation applied to human skin biopsy specimens using single doses of 7 000 and 8 000 R resulted in an increase of basement membrane zone antibody binding of 2-3 titre dilution steps. An increase of 3-4 titre dilution steps was achieved by irradiation with ultraviolet light. Infrared irradiation of skin biopsy specimens, on the contrary, caused the total loss of the basement membrane zone fluorescence. It merits further study, whether these contrary effects on the basement membrane zone antibody binding of human skin in vitro (activation of bound antigen after X-ray or ultraviolet irradiation and inactivation of antigen caused by infrared irradiation) are of clinical value concerning the bullous pemphigoid problem in vivo.
两名大疱性类天疱疮患者接受了放射性钴或电子加速器照射治疗。此后，未照射部位的皮肤出现了水疱性皮疹。从文献中可知，对大疱性类天疱疮患者外观正常的皮肤进行紫外线照射，会在照射部位的皮肤产生新的组织学和免疫组化变化。对人体皮肤活检标本单次给予7000伦琴和8000伦琴的X射线照射，导致基底膜带抗体结合增加2 - 3个滴度稀释步骤。紫外线照射可使滴度增加3 - 4个稀释步骤。相反，对皮肤活检标本进行红外线照射会导致基底膜带荧光完全消失。这些体外对人体皮肤基底膜带抗体结合的相反作用（X射线或紫外线照射后结合抗原的激活以及红外线照射导致的抗原失活）在体内对于大疱性类天疱疮问题是否具有临床价值，值得进一步研究。
