Cochrane A D, Bell R, Sullivan J R, Shaw J
Med J Aust. 1979 Nov 3;2(9):501-2.
Ciramadol (WY 15705), a new analgesic and narcotic antagonist was studied on oral-dose form in 16 patients (15 of whom were suffering from malignant disease) to evaluate the analgesic dose and toxicity. Patients with mild or moderate pain experienced effective relief with doses of from 20 mg to 60 mg (mean dose, 47 mg). In patients with moderate to severe pain, effective pain control was not achieved (mean dose, 82 mg). There was no consistent effect on blood pressure level, heart rate, or respiratory rate. Mild or moderate sedation occurred in eight patients. Nausea and vomiting occurred in two patients.
环拉马朵（WY 15705）是一种新型镇痛药和麻醉拮抗剂，对16例患者（其中15例患有恶性疾病）的口服剂型进行了研究，以评估镇痛剂量和毒性。轻度或中度疼痛的患者服用20毫克至60毫克（平均剂量47毫克）后疼痛得到有效缓解。中度至重度疼痛的患者未实现有效的疼痛控制（平均剂量82毫克）。对血压水平、心率或呼吸频率没有一致的影响。8例患者出现轻度或中度镇静。2例患者出现恶心和呕吐。
