Pawłowski L, Ruczyńska J, Przegaliński E
Pol J Pharmacol Pharm. 1980 Jul-Aug;32(4):539-50.
Thyroliberin (TRH) (0.5-4 mg/kg) enhanced the flexor reflex (increase in the reflex amplitude) in a dose-dependent way. A similar though weaker effect was exerted by one of its analogues examined in our experiment (Pyr-His-Pro-NH-NH2 . 2HCI, 2--8 mg/kg). The other two analogues tested (Pyr-Tyr-Pro-NH2 and Pic-His-Pro-NH2) were inactive in this respect. TRH (0.5-8 mg/kg) produced no effect on the neuro-muscular transmission. Serotoninolytics (metergoline, pizotifen) and noradrenolytics (phenoxybenzamine, haloperidol) did not counteract the TRH-induced stimulation of the reflex. On the other hand, ti was found that TRH enhanced the stimulating effect of LSD and, especially, of clonidine on the flexor reflex. The results obtained suggest that the stimulatory action of TRH on the flexor reflex is not connected with its direct effect either on the serotoninergic or nonradrenergic transmission, and that TRH increases the reactivity of central noradrenaline receptors and, to a smaller extent, of serotonin ones.
促甲状腺素释放激素（TRH）（0.5 - 4毫克/千克）以剂量依赖的方式增强了屈肌反射（反射幅度增加）。在我们的实验中检测的其一种类似物（Pyr - His - Pro - NH - NH₂·2HCl，2 - 8毫克/千克）也产生了类似但较弱的效果。测试的另外两种类似物（Pyr - Tyr - Pro - NH₂和Pic - His - Pro - NH₂）在这方面没有活性。TRH（0.5 - 8毫克/千克）对神经肌肉传递没有影响。血清素分解剂（美替拉酮、苯噻啶）和去甲肾上腺素分解剂（酚苄明、氟哌啶醇）并未抵消TRH诱导的反射刺激。另一方面，发现TRH增强了LSD，尤其是可乐定对屈肌反射的刺激作用。获得的结果表明，TRH对屈肌反射的刺激作用与其对血清素能或去甲肾上腺素能传递的直接作用无关，并且TRH增加了中枢去甲肾上腺素受体的反应性，在较小程度上也增加了血清素受体的反应性。
