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Metabolism of 8,11,14-eicosatrienoic acid in human platelets.

作者信息

Falardeau P, Hamberg M, Samuelsson B

出版信息

Biochim Biophys Acta. 1976 Aug 23;441(2):193-200. doi: 10.1016/0005-2760(76)90162-4.

DOI:10.1016/0005-2760(76)90162-4
PMID:952987
Abstract

The following labeled compounds were isolated and identified after incubation of 8,11,14-eicosatrien [1-14C] oic acid with human platelets: 12-L-hydroxy-8,10,14-eicosatrienoic acid, 8,11,12-trihydroxy-9,14-eicosadienoic acid, 8,9,12-trihydroxy-10,14-eicosadienoic acid, 12-L-hydroxy-8,10-heptadecadienoic acid, prostaglandin E1, prostaglandin D1, and 8-(1-hydroxy-3-oxopropyl)-9,12-dihydroxy-10-heptadecenoic acid (thromboxane B1).

摘要

相似文献

1
Metabolism of 8,11,14-eicosatrienoic acid in human platelets.
Biochim Biophys Acta. 1976 Aug 23;441(2):193-200. doi: 10.1016/0005-2760(76)90162-4.
2
An epoxy-hydroxy product from arachidonate.一种源自花生四烯酸的环氧 - 羟基产物。
Adv Prostaglandin Thromboxane Res. 1980;6:107-9.
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The identification of an epoxy-hydroxy acid as a product from the incubation of arachidonic acid with washed blood platelets.环氧羟基酸作为花生四烯酸与洗涤过的血小板孵育产物的鉴定。
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Isolation of a new lipoxygenase metabolite of arachidonic acid, 8. 11, 12-trihydroxy-5,9,14-eicosatrienoic acid from human platelets.从人血小板中分离出一种新的花生四烯酸脂氧合酶代谢产物，8,11,12-三羟基-5,9,14-二十碳三烯酸。
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Conversion of 8,11,14-eicosatrienoic acid to 11,12-epoxy-10-hydroxy-8-heptadecenoic acid by aorta.主动脉将8,11,14-二十碳三烯酸转化为11,12-环氧-10-羟基-8-十七碳烯酸。
Prostaglandins. 1983 Feb;25(2):299-309. doi: 10.1016/0090-6980(83)90112-0.
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Biosynthesis of thromboxane B2: assay, isolation, and properties of the enzyme system in human platelets.血栓素B2的生物合成：人血小板中酶系统的测定、分离及特性
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Metabolism of 7,10,13,16-docosatetraenoic acid to dihomo-thromboxane, 14-hydroxy-7,10,12-nonadecatrienoic acid and hydroxy fatty acids by human platelets.人血小板将7,10,13,16-二十二碳四烯酸代谢为二高血栓烷、14-羟基-7,10,12-十九碳三烯酸和羟基脂肪酸。
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Differential regulation of the formation of prostaglandins and related substances from arachidonic acid and from dihomogammalinolenic acid. II. Effects of vitamin C.花生四烯酸和二高-γ-亚麻酸生成前列腺素及相关物质的差异调节。II. 维生素C的作用。
Prostaglandins Med. 1979 Aug;3(2):129-37. doi: 10.1016/0161-4630(79)90080-6.
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Oxygenation of 5,8,11-eicosatrienoic acid by prostaglandin endoperoxide synthase and by cytochrome P450 monooxygenase: structure and mechanism of formation of major metabolites.前列腺素内过氧化物合酶和细胞色素P450单加氧酶对5,8,11-二十碳三烯酸的氧化作用：主要代谢产物的结构与形成机制
Arch Biochem Biophys. 1993 Sep;305(2):288-97. doi: 10.1006/abbi.1993.1425.

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Evidence for a lipoxygenase mechanism in the biosynthesis of epoxide and dihydroxy leukotrienes from 15(S)-hydroperoxyicosatetraenoic acid by human platelets and porcine leukocytes.人血小板和猪白细胞由15(S)-氢过氧化二十碳四烯酸生物合成环氧化物和二羟基白三烯过程中脂氧合酶机制的证据。
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