Agner E, Larsen J H
Scand J Respir Dis. 1979 Oct;60(5):230-4.
Sarcoidosis of recent onset was diagnosed during a Yersinia enterocolitica infection in seven patients at the Copenhagen County Hospitals during a 3 1/2 year period. In all cases the diagnosis was made from clinical symptoms and confirmed by chest X-ray and biopsy. In five of the patients a fourfold rise or decrease was measured in the antibody titre against Yersinia enterocolitica, serotype 3, confirming an acute infection. In another two patients this titre remained significantly elevated greater than or equal to 80, indicating chronic infection. Five patients experienced joint symptoms and four erythema nodosum, symptoms common to both yersiniosis and sarcoidosis. A follow-up examination 14 to 41 months after the debut of sarcoidosis showed total remission (including chest X-ray and respiratory function) in five of the seven patients. Recent research has shown that Yersinia enterocolitica following the early stage of the infection causes granulomatous lesions in lymph follicles, and this aetiology should thus be considered as a differential diagnosis to sarcoidosis.
在哥本哈根郡医院的3年半时间里，7例近期发病的结节病患者在小肠结肠炎耶尔森菌感染期间被确诊。所有病例均根据临床症状做出诊断，并通过胸部X光和活检得到证实。其中5例患者针对3型小肠结肠炎耶尔森菌的抗体滴度出现四倍升高或降低，证实为急性感染。另外2例患者该滴度持续显著升高，大于或等于80，表明为慢性感染。5例患者出现关节症状，4例出现结节性红斑，这两种症状在耶尔森菌病和结节病中均较为常见。结节病首次出现后14至41个月的随访检查显示，7例患者中有5例完全缓解（包括胸部X光和呼吸功能）。最近的研究表明，小肠结肠炎耶尔森菌在感染早期会导致淋巴滤泡出现肉芽肿性病变，因此这种病因应被视为结节病的鉴别诊断。
