Lykkesfeldt G, Osler M
Acta Obstet Gynecol Scand. 1979;58(4):321-5. doi: 10.3109/00016347909154590.
A study of labor induction in 325 patients is reported. Group I (77 patients with Bioshop's scores 0-6) and 2 (69 patients with Bishop's scores 7-12) were given 0.5 mg prostaglandin E2 every half hour (maximum 5 mg per day). Group 3 (87 patients with Bishop's scores 0-6) was givne 50 International units of buccal desaminooxytocin every half hour (maximum 500 International units per day). In Group 4 (92 patients with Bishop's scores 7-12), labor was induced by primary amniotomy and automatic oxytocin infusion by the Cardiff method. In groups 1, 2 and 3, 45 per cent, 74 per cent and 41 per cent delivered within 48 hours, while 100 per cent in group 4 delivered within 24 hours. No differences were found in either the frequency of cesarean section or the incidence of low Apgar scores. A higher, but not statistically significant frequency of vacuum extraction was found in the Cardiff group (25 per cent) than in the tablet-induced groups (15 per cent). There was, however, a significantly higheroccurrence of alterations in fetal heart rate which led to instrumental intervention to hasten delivery in the Cardiff group compared to the tablet-induced patients.
本文报告了一项对325例患者进行引产的研究。第一组（77例Bishop评分0 - 6分的患者）和第二组（69例Bishop评分7 - 12分的患者）每半小时给予0.5毫克前列腺素E2（每天最大剂量5毫克）。第三组（87例Bishop评分0 - 6分的患者）每半小时给予50国际单位的口腔去氨加压素（每天最大剂量500国际单位）。第四组（92例Bishop评分7 - 12分的患者）通过初次破膜和采用加的夫方法自动输注缩宫素引产。在第一、二和三组中，分别有45%、74%和41%的患者在48小时内分娩，而第四组100%的患者在24小时内分娩。剖宫产频率和低Apgar评分发生率均无差异。加的夫组（25%）采用真空吸引术的频率高于片剂引产组（15%），但差异无统计学意义。然而，与片剂引产的患者相比，加的夫组胎儿心率改变导致采用器械助产加速分娩的发生率显著更高。
