Nelson G H, Bryans C I
Am J Obstet Gynecol. 1976 Nov 1;126(5):549-54. doi: 10.1016/0002-9378(76)90746-8.
The efficacy of oral prostaglandin E2 (PGE2) for induction of labor has been compared to that of intravenous oxytocin. There were 49 patients in each series. The over-all success rate with PGE2 is 82 per cent; with oxytocin, 65 per cent. PGE2 is at least as effective as oxytocin regardless of Bishop score or gravidity. There was no difference in the duration of labor in successful inductions with PGE2 or oxytocin. Nausea and diarrhea are more common with PGE2 but in only one case was this severe enough to warrent discontinuing the medication. One case of uterine hypertonus occurred in each series. No serious harmful effects on mother or fetus were noted with PGE2. These data support the concept that oral PGE2 administration is a safe and effective alternative to intravenous oxytocin for induction of labor in normal and high-risk pregnancies.
已将口服前列腺素E2（PGE2）引产的疗效与静脉注射缩宫素的疗效进行了比较。每个系列各有49例患者。PGE2的总体成功率为82%；缩宫素为65%。无论 Bishop 评分或妊娠次数如何，PGE2至少与缩宫素一样有效。使用PGE2或缩宫素成功引产的产程没有差异。PGE2更常出现恶心和腹泻，但只有1例严重到足以停药。每个系列各发生1例子宫张力过高。未发现PGE2对母亲或胎儿有严重有害影响。这些数据支持这样一种观念，即在正常和高危妊娠中，口服PGE2是静脉注射缩宫素引产的一种安全有效的替代方法。
