Varnek L, Schnohr P, Jensen G
Acta Ophthalmol (Copenh). 1979 Oct;57(5):755-65. doi: 10.1111/j.1755-3768.1979.tb01841.x.
The results of blood-lipid screening of 200 39--49-year-old participants with incidentally diagnosed corneal arcus from the Copenhagen City Heart Study are reported. A large sample of study-participants of the same age-group without arcus served as controls. In general, the arcus-group had higher se.-cholesterol than the control-group (P less than 0.01 in males and less than 0.02 in females). The se.-triglycerides in the two groups did not differ. A trend towards positive correlation between arcus-intensity and cholesterol-level was demonstrated by non-parametrical statistics. By use of the same statistics, an association between lipids and arcus-localisation was searched out. Dense arcus in the nasal/lower limbal regions occurred together with hypercholesterolemia more often than did a marked upper/outer arcus. Consequently, based on the present investigation, se.-cholesterol-screening of middle-aged persons with marked lower/nasal arcus seems justified, since hypercholesterolemia might will be an underlying cause. Finally, the importance of diagnosing and treating hypercholesterolemia is briefly discussed.
报告了哥本哈根市心脏研究中200名39至49岁偶然诊断为角膜弓的参与者的血脂筛查结果。一大组同年龄组无角膜弓的参与者作为对照。总体而言，角膜弓组的血清胆固醇高于对照组（男性P<0.01，女性P<0.02）。两组的血清甘油三酯无差异。非参数统计显示角膜弓强度与胆固醇水平呈正相关趋势。使用相同的统计方法，研究了脂质与角膜弓定位之间的关联。鼻侧/下角膜缘区域的致密角膜弓与高胆固醇血症同时出现的频率高于明显的上侧/外侧角膜弓。因此，基于目前的研究，对有明显下侧/鼻侧角膜弓的中年人进行血清胆固醇筛查似乎是合理的，因为高胆固醇血症可能是潜在原因。最后，简要讨论了诊断和治疗高胆固醇血症的重要性。
