角膜弓与高脂血症：老年人群的研究结果

Corneal arcus and hyperlipidemia: findings from an older population.

作者信息

Chua Brian E, Mitchell Paul, Wang Jie Jin, Rochtchina Elena

机构信息

Department of Ophthalmology, the University of Sydney, Sydney, Australia.

出版信息

Am J Ophthalmol. 2004 Feb;137(2):363-5. doi: 10.1016/S0002-9394(03)00902-4.

DOI:10.1016/S0002-9394(03)00902-4

PMID:14962437

Abstract

PURPOSE

To quantify the association between arcus and hyperlipidemia in an older population.

DESIGN

Cross-sectional population-based study.

METHODS

Arcus and serum lipids were measured in the Blue Mountains Eye Study (n = 3,654, aged >49 years). Arcus was graded as absent, partial (<180 degrees) or circumferential (> or =180 degrees). Associations between arcus and hyperlipidemia were assessed using logistic regression, adjusting for age and vascular risk factors.

RESULTS

Arcus was strongly associated with age (P <.0001). After age adjustment, arcus was associated with male sex (P <.01) and diabetes (P <.02) but not with hypertension or smoking. Corneal arcus was significantly associated with progressively higher levels of total cholesterol over 5 mmol/l. Adjusted odds increased from 1.6 for cholesterol 6.0 to 6.9 mmol/l to 4.6 for cholesterol >8.0 mmol/l, and was 1.9 for high triglyceride >3.0 mmol/l.

CONCLUSION

This population-based finding confirms that corneal arcus was associated with hypercholesterolemia and hypertriglyceridemia in older persons.

摘要

目的

量化老年人群中角膜弓与高脂血症之间的关联。

设计

基于人群的横断面研究。

方法

在蓝山眼研究中（n = 3654，年龄>49岁）测量角膜弓和血脂。角膜弓分为无、部分（<180度）或环形（≥180度）。使用逻辑回归评估角膜弓与高脂血症之间的关联，并对年龄和血管危险因素进行校正。

结果

角膜弓与年龄密切相关（P <.0001）。年龄校正后，角膜弓与男性（P <.01）和糖尿病（P <.02）相关，但与高血压或吸烟无关。角膜弓与总胆固醇水平逐渐升高至超过5 mmol/l显著相关。校正后的比值比从胆固醇为6.0至6.9 mmol/l时的1.6增加到胆固醇>8.0 mmol/l时的4.6，高甘油三酯>3.0 mmol/l时为1.9。